LYMPHOVASCULAR INVASION (LVI) IN OVARIAN EPITHELIAL CANCER: A DETERMINANT OF FIGO 2014 STAGE

Authors

• Intan Septia. J, Medical student, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia
• Aswiyanti Asri, Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, West Sumatera, IndonesiaFollow
• Puja Agung Antonius, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia
• Shinta Ayu Intan, Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia
• Almurdi Almurdi, Department of Microbiology, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia

ORCID ID

Intan Septia. J: https://orcid.org/0009-0001-0349-4806

Aswiyanti Asri: https://orcid.org/0000-0001-7073-3240

Puja Agung Antonius: https://orcid.org/0000-0003-2449-4327

Shinta Ayu Intan: https://orcid.org/0009-0001-1540-0440

Almurdi: https://orcid.org/0009-0009-4897-8984

Abstract

Ovarian epithelial cancer is an ovarian malignancy with the highest mortality rate in gynecologic oncology. Its incidence increases after the age of 50 and is associated with various risk factors. Carcinogenesis is driven by factors such as incessant ovulation, gonadotropin stimulation, and postmenopausal hormonal fluctuations. These factors cause DNA damage in ovarian epithelial cells through specific molecular pathways, resulting in diverse histopathological types and subtypes. Furthermore, the disease's progression and staging are significantly impacted by its pathways of spread via blood vessels and lymphatics known as LVI (Lymphovascular Invasion). This study employed a comparative observational analytical design with a cross-sectional approach. Consecutive sampling was used to recruit patients diagnosed with ovarian epithelial cancer between 2022 and 2023 at the Anatomical Pathology Diagnostic Center of Dr. M. Djamil Hospital in Padang. The research was conducted from August 2023 to September 2024. Data were analyzed using the Chi-square test. Bivariate analysis revealed a statistically significant relationship between Lymphovascular Invasion (LVI) and the FIGO 2014 stage, with a p-value of 0.007 (p < 0.05). In conclusion, lymphovascular invasion (LVI) is associated with the FIGO 2014 stage in ovarian epithelial cancer and may play an important role in disease progression and staging.

Keywords

Epithelial Ovarian Cancer; LVI; FIGO 2014 Staging; Cancer prognosis; Early detection; Women's health

First Page

100

Last Page

108

DOI

10.65346/2599-056X.2434

Publication Date

6-30-2026

Recommended Citation

J, Intan Septia.; Asri, Aswiyanti; Antonius, Puja Agung; Intan, Shinta Ayu; and Almurdi, Almurdi. 2026 LYMPHOVASCULAR INVASION (LVI) IN OVARIAN EPITHELIAL CANCER: A DETERMINANT OF FIGO 2014 STAGE. Folia Medica Indonesiana. 62, 1 (Jun. 2026 ), 100-108.
Available at: https://doi.org/10.65346/2599-056X.2434